Cancer gene therapy

Cancer Gene Ther · ISSN (e) 1476-5500 · 1 paper in corpus

lab-animal 2025

Therapeutic targeting of the tryptophan-kynurenine-aryl hydrocarbon receptor pathway with apigenin in MED12-mutant leiomyoma cells

doi:10.1038/s41417-025-00881-0 ·PMID:40025195

Approximately 77.4% of uterine leiomyomas carry MED12 gene mutations (mut-MED12), which are specifically associated with strikingly upregulated expression and activity of the tryptophan 2,3-dioxygenase (TDO2) enzyme, leading to increased co…