Alzheimer's & dementia : the journal of the Alzheimer's Association

IntroductionNeuritin-1 (NRN1) was identified as a synaptic protein associated with cognitive resilience to Alzheimer's disease (AD).MethodsTarget risk score and cell type expression profiles were generated for NRN1 using methods developed b…

Growing evidence underscores the importance of cardiovascular contributions to Alzheimer's disease and related dementias (AD/ADRD). While sex differences in cardiovascular disease (CVD) risk factors and outcomes are well established, the qu…

IntroductionPremenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity.MethodsFemale participants …

IntroductionAnalysis of sequence data in high-risk pedigrees is a powerful approach to detect rare predisposition variants.MethodsRare, shared candidate predisposition variants were identified from exome sequencing 19 Alzheimer's disease (A…