Journal of orthopaedic translation

lab-animal 2022

Melatonin suppresses bone marrow adiposity in ovariectomized rats by rescuing the imbalance between osteogenesis and adipogenesis through SIRT1 activation

doi:10.1016/j.jot.2022.10.002 ·PMID:36381247

INTRODUCTION: Accelerated imbalance between bone formation and bone resorption is associated with bone loss in postmenopausal osteoporosis. Studies have shown that this loss is accompanied by an increase in bone marrow adiposity. Melatonin …

lab-animal 2022

Puerarin specifically disrupts osteoclast activation via blocking integrin-β3 Pyk2/Src/Cbl signaling pathway

doi:10.1016/j.jot.2022.01.003 ·PMID:35228997

OBJECTIVE: Given the limitations of current anti-resorption agents for postmenopausal osteoporosis, there is a need for alternatives without impairing coupling crosstalk between bone resorption and bone formation ie. osteoclastogenesis. Pue…

review 2018

Informed appropriate imaging for low back pain management: A narrative review

doi:10.1016/j.jot.2018.07.009 ·PMID:30258783

Most patients with acute low back pain (LBP), with or without radiculopathy, have substantial improvements in pain and function in the first 4 weeks, and they do not require routine imaging. Imaging is considered in those patients who have …