Wang X

RNA modification has been established as a pivotal field in epitranscriptomics, representing an emerging, dynamic, and precise regulatory layer in gene expression control. N6-methyladenosine (m6A), the most prevalent internal RNA modificati…

The age-related decline in oocyte quality constitutes a major cause of reduced female fertility. In this study, we investigated the potential of stromal cell-derived factor-1 (SDF-1) to counteract oocyte deterioration during reproductive ag…

Varicocele-induced decline in sperm quality is a common cause of male infertility. While varicocelectomy improves semen parameters, the mechanisms remain unclear. Recent studies suggested that small noncoding RNAs (sncRNAs) in sperm play a …

Females with iron overload suffer from follicular dysplasia, and effective therapeutic strategies for preserving fertility remain lacking. As a natural aliphatic polyamine, spermidine exerts antioxidant activity and plays an anti-ferroptosi…

BackgroundPyometra is an uncommon gynecologic disorder characterized by the accumulation of pus within the uterine cavity typically resulting from cervical obstruction. Spontaneous perforation of pyometra (SPP) is extremely rare but may rap…

Oral delivery of protein and peptide therapeutics (PPs) offers a non-invasive, patient-friendly alternative to parenteral administration, yet faces multiple formidable barriers due to the complex gastrointestinal (GI) environment. This revi…

INTRODUCTION: Adenomyosis, which affects > 20% of reproductive-age women, is a major cause of infertility. Defective decidualization of endometrial stromal cells (ESCs) is a key pathogenic feature of adenomyosis; however, the underlying red…

BackgroundImplantation failure is the most common cause of pregnancy failure and is a major limiting factor in assisted reproduction. Plasma microRNA (miRNA) expression profiles show dynamic changes among individuals with successful implant…

OBJECTIVE: This study aimed to investigate the variations in junctional zone (JZ) ultrasonographic parameters using three-dimensional transvaginal ultrasound (3D-TVS) across different age groups and evaluate their diagnostic potential for a…

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide that has garnered significant attention due to its potential multiple antitumor mechanisms. This review first explores the current statuses and challenges faced in tumor preventi…

Fibrosis is a defining feature of endometriosis (EMS). Our previous single-cell RNA sequencing (scRNA-seq) revealed myofibroblasts (MFBs) as the predominant cells in ectopic endometrium (ECE), mainly derived from fibroblast-to-myofibroblast…

Globally, ovarian cancer remains a leading cause of gynecologic cancer death. This poor prognosis is primarily attributed to advanced disease at diagnosis, a high propensity for recurrence, and the inadequate therapeutic efficacy of current…

This study aimed to investigate the pathogenic mechanisms of jaw cysts by screening for differentially expressed proteins in the tissues of patients with jaw cysts using proteomic techniques. Tissue samples were collected from 4 patients wi…

PurposeVaginal natural orifice transluminal endoscopic surgery (vNOTES) is an innovative minimally invasive procedure. The study aimed to evaluate whether vNOTES achieves non-inferior results compared to conventional laparoscopy in patients…

ObjectiveTo evaluate the accuracy of multimodal vaginal ultrasound in assessing post-caesarean scar healing.MethodsA systematic review and meta-analysis were conducted on Chinese and English studies using multimodal vaginal ultrasound to di…

ObjectiveThis study aimed to develop a predictive model for the risk of no usable blastocyst formation in patients with normal ovarian reserve undergoing IVF.MethodsThe model was derived from 7,901 patients who underwent their first oocyte …

Mengmeng Sun,1,2,* Xinyi Deng,3,* Hui Xing,1,4 Rui Zhang,3 Bingbing Fu,1 Tao Ai,5 Fang Wang,6 Xuechun Wang,6 Lei Chen,6 Xiaogang Mao,1,4 Feng Wu3 1Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospi…

Endometriosis (EMS) is a significant contributor to female infertility, with its underlying mechanisms remaining inadequately understood. Animal models serve as essential tools for investigating disease progression and evaluating treatment …

Long noncoding RNA (lncRNA) and N6-methyladenosine (m6A) methylation modification have recently been suggested as potential functional modulators in ovarian endometriosis, however, the function and mechanism of m6A-modified lncRNA in ovaria…

MEIS1::NCOA1/2 fusions have been identified in spindle cell tumors of the gynecologic and genitourinary tracts, as well as in two cases of intraosseous spindle cell rhabdomyosarcomas. These tumors typically exhibit an infiltrative growth pa…

OBJECTIVE: To explore factors related to dysmenorrhea in adenomyosis and construct a risk prediction model. METHODS: A cross-sectional survey involving 1636 adenomyosis patients from 37 hospitals nationwide (November 2019-February 2022) wa…

IntroductionRecurrent pregnancy loss (RPL) is a complex condition with multifactorial causes. This study aimed to characterize the microbial composition of endometrial fluid in RPL patients compared with healthy controls.MethodsA total of 1…

Polycystic ovary syndrome is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression. However, the underlying mechanism remains unc…

Endometritis is a common reproductive disorder in dairy cows, with antibiotics being the primary treatment option. However, the overuse of antibiotics has contributed to the growing problem of antimicrobial resistance. Antimicrobial peptide…