KEY POINTS: Apolipoprotein L1 variants were transported to the plasma membrane via actin filaments, where they exhibited distinct dynamics. Apolipoprotein L1 was functionally expressed at the plasma membrane and formed a voltage-dependent n…
Fifteen years have elapsed since the publication of the seminal work establishing the association between risk variants in the Apolipoprotein L1 (APOL1) gene and kidney disease in individuals of African ancestry. During this period, substan…
Nephropathic cystinosis is an inherited lysosomal storage disorder caused by pathogenic variants in the cystinosin (CTNS) gene and is characterized by the excessive shedding of proximal tubular epithelial cells (PTECs) and podocytes into ur…
Chitotriosidase enzyme (EC: 3.2.1.14) is the major active chitinase in the human body. It is produced mainly by activated macrophages, in which its expression is regulated by multiple intrinsic and extrinsic signals. Chitotriosidase was con…