Lynda J M Juffermans

article 2026

A hypothesis on the aetiology of adenomyosis: is there an association between cumulative number of menstruations and severity of adenomyosis on ultrasound?

European journal of obstetrics & gynecology and reproductive biology: X ·doi:10.1016/j.eurox.2026.100472

RATIONALE: Adenomyosis is a common uterine disorder, yet its aetiology remains debated. The tissue injury and repair (TIAR) hypothesis suggests that repeated microtrauma from menstrual contractions damages the endometrial-myometrial interfa…

other 2025

Anti-angiogenic therapy as potential treatment for adenomyosis

Angiogenesis ·doi:10.1007/s10456-024-09960-6

Adenomyosis is characterized by abnormal uterine bleeding, dysmenorrhea and subfertility. Increased expression of angiogenesis markers in adenomyosis presents a treatment opportunity and was studied in an adenomyosis mouse model. Mice were …

article 2022

Increased Angiogenesis and Lymphangiogenesis in Adenomyosis Visualized by Multiplex Immunohistochemistry

International journal of molecular sciences ·doi:10.3390/ijms23158434

There is evidence for increased angiogenesis in the (ectopic) endometrium of adenomyosis patients under the influence of vascular endothelial growth factor (VEGF). VEGF stimulates both angiogenesis and lymph-angiogenesis. However, informati…