Li Y

INTRODUCTION: Endometriomsis (EMs) is a complex and chronic gynecological disease characterized by distressing symptoms. Its pathogenesis remains unknown, and there is no effective treatment. Therefore, establishing patient-derived models i…

Endometriosis (EMs) is an estrogen-dependent inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity, yet its precise pathogenesis remains incompletely elucidated. TICAM1, a key adaptor prote…

Intrauterine adhesion arise from aberrant repair and fibrotic remodeling after basal endometrial injury. Hysteroscopic adhesiolysis remains the standard treatment, yet postoperative recurrence stays high and durable preventive strategies re…

Lateral flow assays (LFAs) remain central to point-of-care diagnostics because they combine low cost, portability, and operational simplicity. Emerging diagnostic demands, including low-abundance biomarkers, complex sample matrices, quantit…

BACKGROUND: To analyze trends in surgical approach stratified by Body Mass Index (BMI) among women undergoing hysterectomy for benign indications in the United States and to compare clinical outcomes in morbidly obese patients (BMI > 40 kg/…

STUDY QUESTION: What is the incidence of triploidy and genome-wide uniparental disomy (gwUPD) in human embryos currently undetected by conventional preimplantation genetic testing (PGT)? SUMMARY ANSWER: Triploidy and gwUPD were detected in…

Background/Objective: RNA modifications, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), N1-methyladenosine (m1A), pseudouridine (Ψ), N4-acetylcytidine (ac4C), 5-methoxycarbonylmethyl-2-thiouridine (mcm5…

"Wen Tong Plaster" is renowned for its therapeutic effects of warming meridians, dispelling cold, and promoting blood circulation. However, its chemical composition and active pharmacological substances have yet to be fully elucidated. In t…

Uterine tumors resembling ovarian sex-cord tumors (UTROSCT) are rare mesenchymal neoplasms with low malignant potential and polyphenotypic immunoprofiles. A 38-year-old nullipara presented with menorrhagia; trans-vaginal ultrasound revealed…

STUDY OBJECTIVE: To evaluate the effects of a 3-stage treatment strategy featured by cold-knife adenomyomectomy, enhanced endometrial protection and postoperative uterine monitoring for severe diffuse adenomyosis on IVF/ICSI and perinatal o…

BACKGROUND: Chronic endometritis (CE), a persistent inflammatory condition of the endometrial lining, is clinically linked with adverse reproductive outcomes. It is currently hypothesized to be associated with infection, and is often treate…

BACKGROUND: The increasing global incidence of endometrial cancer (EC) underscores the urgent need for effective early detection. Noninvasive detection approaches, such as transvaginal ultrasonography (TVS), frequently exhibit low specifici…

BACKGROUND: Postmenopausal osteoporosis (PMOP) is a metabolic bone disease characterized by decreased bone mass and deteriorated bone microstructure. Despite advancements in hormone-related PMOP research, a systematic bibliometric analysis …

BACKGROUND: Immature teratoma is a malignant tumor and accounts for 1%-3% of ovary teratoma. The objective of this study was to find the potential single nucleotide polymorphisms (SNPs), copy number variations (CNVs) and drug targets in the…

The Australasian CREI (Certificate of Reproductive Endocrinology and Infertility) Consensus Expert Panel on Trial Evidence (ACCEPT) group recently published an evidence-based guideline on the investigation and management of recurrent pregna…

PURPOSE: To establish a diagnostic model combining contrast-enhanced ultrasound (CEUS), human epididymis protein 4 (HE4), and Ovarian-Adnexal Reporting and Data Systems (O-RADS) US v2022, verify its diagnostic efficacy, and compare it with …

Endometrial immune disorders create an inhospitable endometrial environment for embryonic nidation in endometriosis. CD8 + tissue resident memory T cells (CD8 +TRM) are abundant tissue resident immune cells in endometrium, but the effect of…

Adenomyosis is characterized by the invasion of endometrial glands and stroma into the myometrium. Its clinical manifestations often include dysmenorrhoea, excessive menstrual bleeding and infertility. Reduced pregnancy and live birth rates…

Although Müllerian adenosarcoma of the uterus shows weak malignant potential, there are still some factors indicating a worse prognosis. An incontinuous pelvic pain with urinary frequency, urgency, and hypouricemia arose in a mid-70s woman …

This study investigates the role of allograft inflammatory factor 1 (AIF-1) in regulating the proliferation, invasion, and migration of endometrial stromal cells (ESCs) in the context of endometriosis, focusing on its impact on mitochondria…

OBJECTIVE: Following a significant relaxation of restrictions in China on December 7, 2022, after a surge in SARS-CoV-2 infections, an uptick in women presenting with menstrual disorders was observed in clinics. This study aimed to explore …

BACKGROUND: Adenomyosis, a common gynecological disorder in women of reproductive age, is characterized by endometrial invasion into the myometrium, leading to uterine enlargement and smooth muscle hypertrophy. Typical clinical symptoms inc…

OBJECTIVE: To identify the determinants influencing clinical pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. METHODS: A retrospective analysis was conducted on patients who underwent FET at the Department of Reproductive …

At present, there is unclear on the risk factors of recurrence after myomectomy. In this study, we hope to provide reference for the choice of treatment for patients with uterine fibroids and provide basis for the subsequent prediction of r…

OBJECTIVE: To identify if there is a high-risk group for chronic endometritis (CE) in infertile women. METHODS: A retrospective single-center cohort study was conducted on 209 infertile women with CE and 843 women without. Both univariate …