Wang Z

Introduction. Endometriosis affects 10-20% of reproductive-age women. Emerging evidence links the gut microbiota to endometriosis pathogenesis, but observational studies are limited by confounding, reverse causation and uncertainty about wh…

Endometriosis is a prevalent gynecologic disorder that significantly impacts women's health. However, its underlying pathogenesis remains unknown. This study aimed to ascertain causal associations between plasma protein levels and endometri…

Follicular development is a complex and dynamic biological process involving coordinated interactions among endocrine regulation, cellular metabolism, redox homeostasis, mitochondrial function, and immune signaling. Increasing evidence indi…

Background/Objective: RNA modifications, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), N1-methyladenosine (m1A), pseudouridine (Ψ), N4-acetylcytidine (ac4C), 5-methoxycarbonylmethyl-2-thiouridine (mcm5…

BACKGROUND: Polycystic ovary syndrome is a common endocrine disorder, characterized by oligomenorrhea and androgen excess. Only a few studies have addressed the natural history of menstrual cycles among women with polycystic ovary syndrome …

Combined pulmonary fibrosis and emphysema (CPFE) and lung cancer cast intertwined shadows, yet the molecular nexus binding them remains largely obscured. By integrating high-resolution transcriptomic landscapes, extensive genome-wide associ…

ObjectivesAcute pancreatitis, recurrent acute pancreatitis, and chronic pancreatitis are recognized as a continuum of pancreatic diseases. Recurrence increases the risk of progression to chronic pancreatitis. The aim of this study was to se…

OBJECTIVE: Preterm birth is a major global health issue, with higher rates observed in pregnancies following assisted reproductive technology (ART). This study aimed to develop and validate via the validation set a prediction model for pret…

OBJECTIVE: The aim of this study was to investigate the emotional experience of patients with thin endometrium (TE) who have repeatedly cancelled their cycles due to unsuitability for embryo implantation during the endometrial preparation p…

PURPOSE: ARID1A, encoding a component of the switch/sucrose nonfermentable complex, is frequently mutated in urothelial carcinoma. However, its specific impacts on clinical outcomes and CD8+ T-cell functions in urothelial carcinoma remain p…

BackgroundMethylenetetrahydrofolate reductase (MTHFR) regulates folate metabolism and homocysteine (Hcy) methylation. Impaired folate metabolism and vitamin D deficiency are both closely associated with female reproductive disorders, but th…

UNLABELLED: Primary dysmenorrhea (PDM) is a common cyclic menstrual pain that significantly affects the quality of life for women. Several epidemiological studies have suggested a potential association between PDM and mental health traits, …

Hepatocellular carcinoma (HCC) mainly depends on liver fibrosis/cirrhosis, which is regulated by tumor cells and the tumor microenvironment (TME), and is a crucial factor in tumor progression. This study aimed to identify abnormally express…

BACKGROUND: Fibrogenesis is a common pathological feature of endometriotic lesions and contributes to the development of endometriosis-associated chronic pelvic pain and infertility. TGF-β is a critical factor in the induction of fibrogenes…

Chemokines, a category of cytokines exhibiting chemotactic properties, have been thoroughly investigated as targets in cancer treatment in recent decades. In oral squamous cell carcinoma (OSCC), a prevalent and high-risk malignancy of the h…

This review article focuses on the role of choline in ovarian follicular development, regulated by nutrient-epigenetic interactions. Choline, a key feed additive, participates in DNA methylation and steroid hormone synthesis via its methyl …

OBJECTIVE: To compare surgical outcomes of laparoendoscopic single-site myomectomy (LESS-M) for uterine myomas using barbed suture versus conventional suture. METHODS: Data were collected from all women with uterine myomas who underwent LE…

Isothermal, enzyme-free amplification techniques, such as the hybridization chain reaction (HCR) and catalytic hairpin assembly (CHA), have gained significant attention for mRNA analysis. Despite their potential, these methods still face ch…

BACKGROUND: Psoriasis is closely associated with metabolic health. The Cardiometabolic Index (CMI) is an innovative and easily obtainable metric employed to assess cardiometabolic health. This study aims to examine the possible relationship…

OBJECTIVE: To investigate the correlation between endometriosis (EMs) severity and placenta accreta spectrum (PAS) risk in the subsequent pregnancy. METHOD: Clinical records of 2,142 patients who underwent laparoscopic surgery for EMs at F…

Abstract Background: Endometrial receptivity, a critical prerequisite for successful pregnancy, is impaired in women with endometriosis. Plasma membrane transformation (PMT), a key process involving dynamic remodeling of endometrial epithe…

OBJECTIVE: The study aimed to explore the effects of platelet-rich plasma (PRP) gel on vaginal microecology and stump healing, as well as its underlying mechanism. METHODS: From December 2022 to August 2024, 100 patients who underwent lapa…