The age-related decline in oocyte quality constitutes a major cause of reduced female fertility. In this study, we investigated the potential of stromal cell-derived factor-1 (SDF-1) to counteract oocyte deterioration during reproductive ag…
PURPOSE: To screen drug targets of ovarian aging from a genetic perspective. METHODS: Systematic analyses were conducted with cis-expression quantitative trait loci data of druggable genes extracted as instrument variables. Summary statist…
BACKGROUND: Fertility status is a marker of future health, and female infertility has been shown to be an important medical and social problem. Life's Essential 8 ("LE8") is a comprehensive cardiovascular health assessment proposed by the A…
BACKGROUND: Primary Sjögren syndrome (pSS) is often related to adverse neonatal outcomes. But it's currently controversial whether pSS has an adverse effect on female fertility and clinical pregnancy condition. More importantly, it's unclea…
BACKGROUND: Systemic lupus erythematosus (SLE) is often associated with adverse reproductive outcomes. But it's currently unclear regarding the role of SLE in oocyte and embryonic development. Also, it's controversial whether SLE has an adv…