Samo Turk

No ORCID on file · 2 papers in corpus · active 2011

Study types

  • other 2

Condition tags

  • endometriosis 2
other 2011
Design and synthesis of substrate mimetics based on an indole scaffold: potential inhibitors of 17β-HSD type 1
Hormone molecular biology and clinical investigation ·doi:10.1515/HMBCI.2011.012

BACKGROUND: Human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) acts at a pre-receptor level. It catalyzes NADPH-dependent reduction of the weak estrogen estrone into the most potent estrogen estradiol, which exerts its proliferative e…

other 2011
Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1
Journal of medicinal chemistry ·doi:10.1021/jm101104z

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is an enzyme that catalyzes NADPH-dependent reduction of the weak estrogen, estrone, into the most potent estrogen, estradiol, which exerts proliferative effects via the estrogen receptors.…