Francis Jacob

ORCID: 0000-0002-0446-1942 · 4 papers in corpus
2024
Diagnosing and staging epithelial ovarian cancer by serum glycoproteomic profiling.
British journal of cancer ·doi:10.1038/s41416-024-02644-4

BackgroundThere is a need for diagnostic tests for screening, triaging and staging of epithelial ovarian cancer (EOC). Glycoproteomics of blood samples has shown promise for biomarker discovery.MethodsWe applied glycoproteomics to serum of …

2012
Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients.
PloS one ·doi:10.1371/journal.pone.0031885

BackgroundActivation of the Wnt signaling pathway is implicated in aberrant cellular proliferation in various cancers. In 40% of endometrioid ovarian cancers, constitutive activation of the pathway is due to oncogenic mutations in β-catenin…

2012
Serum antiglycan antibody detection of nonmucinous ovarian cancers by using a printed glycan array.
International journal of cancer ·doi:10.1002/ijc.26002

Epithelial ovarian cancer has the highest mortality rate among gynecological cancers. Altered glycosylation is associated with oncogenic transformation producing tumor-associated carbohydrate antigens. We investigated the potential of natur…

article 2011
No benefit from combining HE4 and CA125 as ovarian tumor markers in a clinical setting
Gynecologic Oncology ·doi:10.1016/j.ygyno.2011.02.022

ObjectiveAbout 70% of epithelial ovarian cancer patients (EOC) are diagnosed at advanced stage with a five-year survival rate of only 30%. Whilst CA125 detects peritoneally-spread disease, it has limited sensitivity for early cancers, many …