Olivier Rémi Barbeau

ORCID: 0009-0009-2749-2782 · 1 paper in corpus

2026

Identification of the Piperidyl Urea Derivative BAY-439 as a Potent and Selective Inhibitor of Human Phospholipase A2 Group V (hPLA2-G5) for the Treatment of Inflammatory Pain

Journal of medicinal chemistry ·doi:10.1021/acs.jmedchem.6c00488

Human Phospholipase A2 Group V (hPLA2-G5) is elevated in inflammatory conditions and promotes neutrophil and macrophage recruitment. Its enzymatic activity activates lipid receptors and cytosolic phospholipase A2 (cPLA2), leading to arachid…