Yuelin J. Zhu

ORCID: 0000-0002-6620-9232 · 1 paper in corpus

article 2025

TRα1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility

Scientific reports ·doi:10.1038/s41598-025-86848-5

Abstract Thyroid hormone receptors (TRs) mediate the genomic actions of thyroid hormone. Mutations of THRA gene cause a human disease known as resistance to thyroid hormone (RTHα). We created a mouse model expressing a dominant negative mut…