Bartlett TE

ORCID: 0000-0003-0831-9713 · 2 papers in corpus

2022

Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women.

Genome medicine ·doi:10.1186/s13073-022-01063-5

BackgroundBreast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising pr…

2016

Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution.

Nature communications ·doi:10.1038/ncomms11620

The exact timing and contribution of epigenetic reprogramming to carcinogenesis are unclear. Women harbouring BRCA1/2 mutations demonstrate a 30-40-fold increased risk of high-grade serous extra-uterine Müllerian cancers (HGSEMC), otherwise…