Simon I. R. Lane — Endo Lab

article 2025

Peritoneal Fluid Modulates Redox Balance and RNA Integrity in Mouse Oocytes: Insights into Endometriosis-Related Oxidative Stress

Antioxidants (Basel, Switzerland) ·doi:10.3390/antiox14081018

Reactive oxygen species (ROS) are vital for oocyte development, yet the redox state of peritoneal fluid may differ between health and disease. This study investigates the effects of peritoneal fluid from women with and without endometriosis…

review 2019

Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis

Human Reproduction Update ·doi:10.1093/humupd/dmz012

BACKGROUND: The reproductive impact of adenomyosis and endometriosis is widely researched but the extent of these impacts remains elusive. It has been demonstrated that endometriosis, in particular, is known to result in subfertility but en…

2017

DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes.

Development (Cambridge, England) ·doi:10.1242/dev.153965

Mouse oocytes carrying DNA damage arrest in meiosis I, thereby preventing creation of embryos with deleterious mutations. The arrest is dependent on activation of the spindle assembly checkpoint, which results in anaphase-promoting complex …

preprint 2016

Follicular fluid (FF) of infertile women with endometriosis causes poor oocyte maturation by inducing higher reactive oxygen species (ROS) and DNA damage in mouse oocytes

·doi:10.26226/morressier.573c1512d462b80296c986f3

article 2016

Oocyte maturation arrest in endometriosis is caused by elevated levels of Reactive Oxygen Species and enforced via a DNA Damage Response and the Spindle Assembly Checkpoint pathway

·doi:10.1530/repabs.3.o004

Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)

article 2016

The sensitivity of the DNA damage checkpoint prevents oocyte maturation in endometriosis

Scientific reports ·doi:10.1038/srep36994

Mouse oocytes respond to DNA damage by arresting in meiosis I through activity of the Spindle Assembly Checkpoint (SAC) and DNA Damage Response (DDR) pathways. It is currently not known if DNA damage is the primary trigger for arrest, or if…