Issei Imoto

No ORCID on file · 2 papers in corpus
observational 2020
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Nature genetics ·doi:10.1038/s41588-020-0640-3

The overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the East Asian population, we conducted a genome-wide association study (GWAS) with 212,453 Japanese individuals …

observational 2012
ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas
Histopathology ·doi:10.1111/j.1365-2559.2011.04163.x

AIMS: Actinin-4, encoded by the ACTN4 gene located on chromosome 19q13.2, enhances cell motility by bundling the actin cytoskeleton. We assessed how ACTN4/actinin-4 alterations contribute to the tumorigenesis of ovarian clear-cell adenocarc…