Zhou Y

Nanodrug delivery systems (NDDS) have demonstrated broad application prospects in disease treatment, prevention, and diagnosis due to several advantages, including functionalization capability, high drug-loading capacity, drug stability pro…

BACKGROUND: To investigate the optimal periendometrial zone (PEZ) in ultrasound (US) images and assess the performance of ultrasound radiomics in predicting the outcome of frozen embryo transfer (FET). METHODS: This prospective study had 4…

BACKGROUND: Endometrial thickness independently predicts pregnancy outcomes in frozen embryo transfer (FET) cycles. Thin endometrium always results in implantation failure and worse obstetric-neonatal outcomes. However, it has not been repo…

Peptide- and protein-based therapeutics offer realized and potential benefits to health, due to their potent bioactivity, high specificity, and favorable safety characteristics. However, their widespread clinical application is constrained …

STUDY OBJECTIVE: According to a four-level scale of endometriosis surgical complexity, the 2021 American Association of Gynecologic Laparoscopists (AAGL) endometriosis classification system was externally and prospectively validated. And we…

BACKGROUND: Ovarian endometriosis is a common gynecological condition characterized by the abnormal growth of endometrial-like tissue in locations outside the uterus, and its development remains poorly understood. This study aims to investi…

BACKGROUND: Acute pancreatitis is a prevalent condition in China. A plethora of information pertaining to acute pancreatitis is readily available on the Internet, including on major search engines and various short video applications. The o…

PurposeThis study aims to summarize and analyze the existing research on anxiety and depression within the field of assisted reproduction technology, exploring current hotspots, emerging frontiers, and trends, while offering insights for fu…

Among gynecologic malignancies, ovarian cancer (OC) stands out as a highly aggressive disease with the highest mortality rate and the poorest prognosis. At the beginning stage, it demonstrates high sensitivity to platinum-based chemotherapy…

OBJECTIVE: To investigate the impact of changes in luteinizing hormone (LH) levels during ovulation induction using flexible gonadotropin-releasing hormone antagonist (GnRH-A) regimens in POSEIDON groups 1 and 2 on the clinical outcomes of …

BACKGROUND: Delayed childbearing has become an increasingly prevalent trend, influenced by various psychological and social factors. This study aimed to explore the impact of these factors on the timing of childbirth among women of reproduc…

Pyroptosis is a novel form of programmed cell death that depends on gasdermin-mediated pore formation in the plasma membrane and the release of inflammatory factors. Pyroptosis is closely linked to the occurrence and progression of almost a…

Despite intensive development, P2X7 modulators have struggled in translation due to human genetic variability and species-dependent drug responses. Here, we identify PSFL1191, a portal-of-central-pocket (PCP)-site inhibitor selective for hu…

Autoimmune pancreatitis (AIP) is identified as a severe chronic immune-related disorder in pancreas, including two subtypes. In this study, pancreatic lesions in patients diagnosed as either type 1 AIP or type 2 AIP are examined, and these …

BackgroundWolffian adnexal tumor is a rare type of tumor that was first discovered and reported by Karim-inejad in 1973. Wolffian adnexal tumor lacks specific clinical manifestations and its histological morphology is similar to various oth…

OBJECTIVE: The aim of this study was to enhance the precision of categorization of endometrial lesions in ultrasound images via a data enhancement framework based on deep learning (DL), through addressing diagnostic accuracy challenges, con…

Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, and therefore become one of the most prominent global public health concerns. Puerarin, an isoflavone glycoside derived from Pueraria lobata (Willd.) Ohwi, has been…

This study aimed to investigate the changes of serum carbohydrate antigen 125 (CA125) and prostaglandin E2 (PGE2) in patients with adenomyosis before and after treatment with high-intensity focused ultrasound (HIFU) combined with gonadotrop…

Objective: To investigate the clinical features, diagnosis and treatment of oblique vaginal septum syndrome (OVSS). Methods: The clinical data of 80 patients with OVSS admitted to The Second Hospital of Hebei Medical University from July 20…

OBJECTIVE: This prospective observational study aims to demonstrate the clinical efficacy of dienogest in treating endometriomas with a maximum diameter of ≥4 cm. METHODS: Patients (n = 81) with endometriomas (diameter of ≥4 cm) were enrol…

BACKGROUND: The chronic inflammatory immune response is a significant factor in the pathogenesis of benign gynecological diseases. The systemic immunoinflammatory index (SII) and the platelet-to-lymphocyte ratio (PLR) are commonly available…

PURPOSE: To explore the early diagnostic value of superb microvascular imaging (SMI) features within the rotator cuff gap for frozen shoulder. PATIENTS AND METHODS: This prospective study enrolled patients with acute early-stage frozen sho…

OBJECTIVE: To investigate the effects of different drug treatments on uterine artery blood flow parameters, serum placental growth factor (PLGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and sFlt-1/PLGF in patients with recurrent sponta…

Abstract Endometriosis (EMS) refers to the appearance, growth and infiltration of endometrial tissues (glands and stroma) in the uterine cavity covering the endometrium and other parts of the uterus, repeated bleeding, Rare pelvic and intr…