Lacorazza HD — Endo Lab

2017

Novel tumor-suppressor function of KLF4 in pediatric T-cell acute lymphoblastic leukemia.

Experimental hematology ·doi:10.1016/j.exphem.2017.04.009

Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy in pediatric patients. Despite advances in the treatment of this disease, many children with T-cell ALL (T-ALL) die from disease relapse due to low responses to …

2015

G0S2 modulates homeostatic proliferation of naïve CD8⁺ T cells and inhibits oxidative phosphorylation in mitochondria.

Immunology and cell biology ·doi:10.1038/icb.2015.9

Since its discovery, diverse functions have been attributed to the G0/G1 switch gene 2 (G0S2), from lipid metabolism to control of cell proliferation. Our group showed for the first time that G0S2 promotes quiescence in hematopoietic stem c…

2012

The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells.

PloS one ·doi:10.1371/journal.pone.0038280

Bone marrow hematopoietic stem cells (HSCs) balance proliferation and differentiation by integrating complex transcriptional and post-translational mechanisms regulated by cell intrinsic and extrinsic factors. We found that transcripts of G…