Wu DY

No ORCID on file · 2 papers in corpus · active 2014-2015
2015
Selective coregulator function and restriction of steroid receptor chromatin occupancy by Hic-5.
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2014-1403

Steroid receptors (SRs) bind specific DNA regulatory sequences, thereby activating and repressing gene expression. We previously showed that transcriptional coregulator Hic-5 facilitates glucocorticoid regulation of some genes but blocks gl…

2014
Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1400522111

Ligand activation and DNA-binding dictate the outcome of glucocorticoid receptor (GR)-mediated transcriptional regulation by inducing diverse receptor conformations that interact differentially with coregulators. GR recruits many coregulato…