Daniel D. Buchanan

2019

Discovery of common and rare genetic risk variants for colorectal cancer.

Nature genetics ·doi:10.1038/s41588-018-0286-6

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome…

2018

Identification of nine new susceptibility loci for endometrial cancer.

Nature communications ·doi:10.1038/s41467-018-05427-7

Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we…

article 2013

Immunophenotypic analysis of ovarian endometrioid adenocarcinoma: Correlation with KRAS mutation and the presence of endometriosis

Pathology ·doi:10.1097/pat.0b013e3283650ad7

AimsThe relationship between endometriosis and ovarian endometrioid adenocarcinoma (OEC) is well recognised but it is unclear whether endometriosis positive and negative OECs develop via similar pathogenetic mechanisms.MaterialsSixty-seven …

article 2012

KRAS mutations in ovarian low-grade endometrioid adenocarcinoma: association with concurrent endometriosis

Human pathology ·doi:10.1016/j.humpath.2011.10.009

The association between ovarian endometrioid adenocarcinoma and endometriosis is well established. However, not all endometrioid adenocarcinomas are directly related to endometriosis, and it has been suggested that there may be clinicopatho…