Jennifer Nichols

ORCID: 0000-0002-8650-1388 · 2 papers in corpus · active 2022-2026

Study types

  • other 1
other 2026
Harnessing the murine inner cell mass mechanical environment enhances derivation of in vitro nascent primitive endoderm precursor cells
Development (Cambridge, England) ·doi:10.1242/dev.205226

Stem cell-based models resembling murine blastocysts represent a useful system to investigate subsequent developmental processes. While existing cell lines derived from epiblast and trophectoderm can be aggregated to form 'blastoids', some …

2022
Plakoglobin is a mechanoresponsive regulator of naïve pluripotency
·doi:10.1101/2022.03.13.484158

Biomechanical cues are instrumental in guiding embryonic development and cell differentiation. Understanding how these physical stimuli translate into transcriptional programs could provide insight into mechanisms underlying mammalian pre-i…