Li Z

Ovarian aging, a major contributor to declining fertility in women of advanced reproductive age (ARA), is strongly associated with impaired mitochondrial function within oocytes. Although current mitochondrial-targeted strategies can improv…

PurposeVaginal delivery is the most common mode of childbirth, and women often experience severe uterine contraction pain (UCP) for several days postpartum, which can significantly impair postpartum recovery. Acupuncture has proven efficacy…

ObjectivesThe research aims to leverage machine learning techniques to better understand the diagnosis of myofascial pelvic pain syndrome (MPPS) and to develop useful tools for clinical practice.MethodsThis study retrospectively analyzed cl…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common disorder affecting the reproductive, endocrine, and metabolic systems in women. Dysfunction of granulosa cells (GCs) and imbalance of the immune microenvironment are key pathological …

Abstract Objective To identify risk factors for postoperative pelvic–abdominal infection after total laparoscopic hysterectomy in patients with benign gynecological diseases and to develop and validate a clinically applicable prediction m…

IntroductionConsumer interest in cannabis-derived products remains high, including among women, a growing demographic group. This study examined women's reproductive health claims in cannabis-derived product e-commerce listings to better un…

OBJECTIVE: High-intensity focused ultrasound (HIFU) therapy is increasingly used in the management of various solid tumors. However, limited data are available regarding the association between HIFU treatment and coagulation function. MATE…

PurposeThis study aims to investigate the role of calcitonin gene-related peptide (CGRP) in corneal tissue repair in alkali burn and its underlying neuro-immune mechanisms.MethodsMouse corneal nerves were ablated via surgery or resiniferato…

BackgroudEndometrial cancer (EC), the most prevalent gynecologic malignancy in developed countries, often arises from endometrial atypical hyperplasia (EAH). Thus, how to predict EAH combined with EC before total hysterectomy is particularl…

BACKGROUND: Abnormal angiogenesis plays vital role in the pathogenesis of adenomyosis (AM). Emerging evidence suggests that exosomes derived from endometrial cells can accelerate the progression of AM. In this study, we aim to investigate t…

OBJECTIVE: To investigate the effect of bisphosphonates on surgical site infection (SSI) and their safety in postmenopausal women undergoing Anterior Cervical Discectomy and Fusion (ACDF). METHODS: This was a single-center retrospective coh…

Diminished ovarian reserve (DOR) is associated with poor reproductive outcomes; however, the underlying molecular mechanisms-particularly those involving the regulation of granulosa cell (GC) function by exosomal microRNAs (miRNAs) derived …

Background and objectiveIleal ureter replacement (IUR) is the definitive management approach for extensive ureteral strictures (UrSs). Patients with UrS exhibit poor health-related quality of life (HRQoL). We conducted a long-term, multi-in…

Aging impairs the regenerative capacity and differentiation potential of human adipose-derived stem cells (hASCs), but the mechanisms underlying their functional decline remain unclear. Through systematic functional assays and in vivo exper…

OBJECTIVE: This study aimed to investigate the mechanisms underlying Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1, encoding SF-1) hypomethylation in endometriosis (EMs) and to evaluate the effects of Luoshi Neiyi Prescription (LSNYP…

Ferroptosis is an iron-dependent form of programmed cell death driven by lipid peroxidation, distinct from apoptosis and necrosis. It has been confirmed as a key regulator in hepatocellular carcinoma (HCC). This study systematically elucida…

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. Here w…

Despite recent advancements in diagnostic techniques and infertility treatments, the precise underlying cause of infertility remains elusive in numerous cases. Elevated immune cell levels in the reproductive tract frequently result in decre…

Gallbladder carcinoma, among the most prevalent malignancies of the biliary system, often presents with insidious early symptoms. Delayed diagnosis of incidental gallbladder carcinoma frequently leads to therapeutic delays, significantly co…

ObjectiveTo investigate the impact of both pre- and post-ovulation post-wash total progressive motile sperm count (TPMSC) on pregnancy outcomes in intrauterine insemination (IUI) using husband's sperm (AIH).MethodsThis retrospective cohort …

ObjectiveTo systematically evaluate the associations between paternal factors (age, semen parameters, body mass index, sperm DNA fragmentation index (DFI), and leukocyte count), embryonic ploidy, and the clinical implantation potential of e…

Clinical application of mesenchymal stem cells for endometrial repair has been hampered by variability in cell quality, large-scale production, and uncertainty regarding the optimal delivery route. In this study, we investigated the therape…

Cervical cancer remains a major global health burden, yet current screening tools lack precision in identifying which women with high-risk human papillomavirus (HPV) infection will progress to high-grade lesions or cancer. Within a network-…

BACKGROUND: Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disorder characterized by impaired surfactant clearance due to alveolar macrophage dysfunction. Leuprorelin acetate, a gonadotropin-releasing hormone agonist, is widely us…

BackgroundAbnormalities in ureteral motility often precede morphological changes, and early subtle lesions are easily overlooked, thereby increasing the risk of renal impairment. However, existing imaging assessments tend to focus on qualit…