Wu J

BACKGROUND: Premature ovarian insufficiency (POI) is a condition identified by the decline in ovarian function before the age of 40. The treatment of POI patients deserves in-depth research. This study aimed to explore the impacts of probio…

In the field of genetic breeding, primordial germ cells (PGCs) have become essential cells for gene editing and genetic improvement due to their unique developmental potential and genetic characteristics. However, the low proliferation effi…

Early screening and diagnosis, precise treatment and prognosis prediction are pivotal for enhancing cancer patients' survival rates and for improving their life quality, it is the same case in gynecological malignancies. Among gynecological…

The protein associated with the silencing information regulator 2-associated enzyme1 (SIRT1) is a highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase and a key member of the sirtuin family. SIRT1 plays an essenti…

OBJECTIVE: Surgical site infections (SSI) after hysterectomy constitute significant postoperative complications, affecting patient recovery and healthcare costs. We conducted a systematic review of risk factors for SSI in patients undergoin…

Peripheral nerve injury-induced muscle atrophy is characterized by chronic inflammation and dysregulated macrophage polarization. RUNX1, a transcription factor upregulated in denervated muscle, has been implicated in linking muscle degenera…

Endometriosis is a chronic condition with limited therapeutic options. The molecular aberrations promoting ectopic attachment and interactions with the local microenvironment sustaining lesion growth have been unclear, prohibiting developme…

BACKGROUND: The levonorgestrel-releasing intrauterine system (LNG-IUS) is a widely recognized method for contraception and the management of various gynecological conditions. However, the placement of LNG-IUS can be particularly challenging…

BACKGROUND: To investigate the combined effect of transperineal ultrasound and Shear Wave Elastography (SWE) in the evaluation and monitoring of pelvic floor functions after total hysterectomy. METHODS: Fifty-two women who planned to under…

Total hysterectomy is a relatively intricate surgical procedure in clinical practice. Laparoscopic total hysterectomy has become widely adopted in clinical settings. With the clinical advancement of single-port technology, single-port lapar…

BACKGROUND: EMS (Endometriosis) is characterized by the presence of functional endometrial tissue outside the uterus and is one of the most common gynecological disorders. SOX18 (SYR-related high-mobility group box 18) is a transcription fa…

To investigate the clinical application value of contrast-enhanced ultrasound (CEUS) technology in evaluating blood flow perfusion changes in adenomyosis patients treated with high-intensity focused ultrasound (HIFU) combined with leuprorel…

This study aims to present a case of uterine adenomyosis accompanied by multiple hemorrhagic cerebral infarctions (CIs), summarize therapeutic experiences based on the literature review, and improve the clinical diagnosis and treatment of m…

Epithelial-mesenchymal transition (EMT) is known to play a crucial role in the development of endometriosis (EMs). However, the exact mechanisms involved in EMT regulation in EMs are not well understood. In this study, we performed comprehe…

RATIONALE: MER proto-oncogene tyrosine kinase (MerTK) is a key receptor for the clearance of apoptotic cells (efferocytosis) and plays important roles in redox-related human diseases. We will explore MerTK biology in human cells, tissues, a…

PURPOSE: Observational studies and clinical validation have suggested a link between thyroid dysfunction and an elevated ovarian cancer (OC) risk. However, whether this association indicates a cause-and-effect relationship remains uncertain…

Premature ovarian insufficiency (POI) is defined as the depletion of ovarian function before the age of 40 years. The global prevalence of POI is 3.5%. To date, genetic factors account for 23.5% of the etiology of POI. Herein, a previously …

BACKGROUND: As the cesarean delivery rate continues to rise globally, the treatment of previous cesarean scar defects (PCSD) remains challenging. This study aimed to analyze the variables that may influence the clinical cure rate of patient…

Abstract Many studies have shown that endometriosis can lead to infertility in women of reproductive age, but the mechanism is unknown. Our study aims to explore the pathogenesis of stage IV endometriosis with infertility and the role of c…

Exosomes have the ability to transport RNA/miRNAs and possess immune modulatory functions. Heat stress, a significant limiting factor in the poultry industry, can induce oxidative stress and suppress the immune responses of laying hens. In …

The sperm DNA fragmentation index (DFI) is a metric used to assess DNA fragmentation within sperm. During in vitro fertilization-embryo transfer (IVF-ET), high sperm DFI can lead to a low fertilization rate, poor embryo development, early m…

PURPOSE: This study aimed to evaluate the effectiveness of a random forest (RF) model in predicting clinical pregnancy outcomes from intrauterine insemination (IUI) and identifying significant factors affecting IUI pregnancy in a large Chin…

Ovarian endometrioma (OE), also known as "chocolate cysts," is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, lea…

BACKGROUND: A newly generic microspheres, sustained-release formulation of triptorelin acetate 3.75 mg has been developed. OBJECTIVES: To evaluate the efficacy, pharmacokinetics, and safety of triptorelin 1-month formulation in Chinese pat…

The pervasive use of plastics in numerous industrial sectors has resulted in the circulation of microplastics across diverse ecosystems and food chains, giving rise to mounting concerns regarding their potential adverse impacts on biologica…