Sven Sandin

BackgroundPremenstrual disorders (PMDs) are characterized by affective and physical symptoms before menses, likely due to abnormal sensitivity to normal hormone fluctuations. While sizable heritability has been indicated in twin studies, th…

STUDY QUESTION: What is the association between endometriosis and the type and age of menopause? SUMMARY ANSWER: Women with endometriosis had a 7-fold increased risk of undergoing surgical menopause rather than natural menopause and were m…

ABSTRACT Background Premenstrual disorders (PMDs) are characterized by affective and physical symptoms before menses, likely due to abnormal sensitivity to normal hormone fluctuations. While sizable heritability has been indicated in twin s…

ObjectiveTo examine the associations of infertility, recurrent miscarriage, and stillbirth with the risk of first non-fatal and fatal stroke, further stratified by stroke subtypes.DesignIndividual participant pooled analysis of eight prospe…

Importance: Early menarche and early menopause are associated with increased risk of cardiovascular disease (CVD) in midlife, but little is known about the association between reproductive life span and the risk of CVD. Objective: To invest…

STUDY QUESTION: How does the risk of cardiovascular disease (CVD) vary with type and age of menopause? SUMMARY ANSWER: Earlier surgical menopause (e.g. <45 years) poses additional increased risk of incident CVD events, compared to women wi…

Study questionAre parity and the timing of menarche associated with premature and early natural menopause?Summary answerEarly menarche (≤11 years) is a risk factor for both premature menopause (final menstrual period, FMP <40 years) and ear…