Dong J

Papillary thyroid cancer (PTC) is an endocrine malignancy with a high incidence. PTC metastasizes more frequently in children and teenagers, although survival of these patients is usually considered excellent. Still, research on regulatory …

Uterine cancer (UC) is the most common malignancy of the female reproductive system worldwide, with a continuously rising incidence, posing a significant public health challenge. This study systematically evaluated the burden of UC using th…

Extensive preclinical and clinical studies have shown that exposure to green light-emitting diodes (gLED) exerts analgesic effect. We hypothesized that exposure to gLED alleviates endometriosis-associated pain. To test this, we induced deep…

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most prevalent chronic liver disease worldwide, yet no pharmacological therapy has achieved regulatory approval. Flavonoids, plant-derived polyphenols encompass…

Heart failure (HF) is an important cause of morbidity and mortality worldwide. Here, we aimed to screen potent regulators in HF progression to assist clinicians in the early diagnosis and management of HF patients. The data were downloaded …

OBJECTIVE: To investigate the association between polycystic ovary syndrome (PCOS) and miscarriage risk and to explore the potential causal effect. METHODS: We conducted a retrospective cohort study of 445 women who conceived via in vitro …

BACKGROUND: Higher prepregnancy body mass index (BMI) is a well-established risk factor for adverse neonatal outcomes in IVF-conceived pregnancies; therefore, weight management is important for infertile patients, yet it remains challenging…

OBJECTIVE: This study aims to investigate the association between the dynamics of routine metabolic markers and endometriosis severity. METHODS: A retrospective analysis was conducted on patients diagnosed with endometriosis at Zhongshan H…

Xiaolin Zhong,1,* Weihong Lu,1,* Qi Zhang,1 Jie Dong,1 Hongyang Xiao,2 Ruiqin Tu2 1Department of Gynecology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 366100, People’s Republic of China; 2Department of Gynecology, Zhong…

Endometriosis (EMs) and recurrent miscarriage (RM) represent major reproductive health challenges. This study investigates the involvement of endothelial-mesenchymal transition (EndMT) in these conditions through integrative bioinformatics …

Oocyte aging is closely related to a decline in female fertility, accompanied by increased reactive oxygen species levels and changes in protein posttranslational modifications. However, the role of protein palmitoylation in oocyte aging ha…

Non-invasive liquid biopsy is a promising strategy for ovarian cancer (OC) detection. We evaluated the feasibility and efficacy of a multi-analyte approach combining circulating tumor DNA (ctDNA) detection with protein biomarkers for early …

OBJECTIVE: To study if the transfer of warmed blastocysts without blastocoele re-expansion is effective and safe. METHODS: Three thousand one hundred ninety-six frozen-thawed single blastocyst transfer cycles were conducted. The embryos we…

BACKGROUND: The levonorgestrel-releasing intrauterine system (LNG-IUS) is a widely recognized method for contraception and the management of various gynecological conditions. However, the placement of LNG-IUS can be particularly challenging…

Objectives: Endometriosis is a common gynecologic condition characterized by the presence of endometrial-like tissue outside the uterus, often leading to pelvic pain and infertility. Diagnosis is frequently delayed, with prolonged diagnosti…

Total hysterectomy is a relatively intricate surgical procedure in clinical practice. Laparoscopic total hysterectomy has become widely adopted in clinical settings. With the clinical advancement of single-port technology, single-port lapar…

BACKGROUND: Increased expression of tribbles pseudokinase 3 (TRIB3), which is attributed to increased levels of free fatty acids in the follicular fluid of women with obesity, is correlated with reduced oocyte developmental competence. Conn…

Yufei Liang,1 Lina Mei,2 Qipeng Ning,2 Jiao Zhang,2 Jingying Fei,3 Jie Dong1 1Department of Gynaecology and Obstetrics, Huzhou Maternity & Child Health Care Hospital, Huzhou, People’s Republic of China; 2Department of Digestive, Huzhou Mate…

BACKGROUND: Endometriosis involves the intestine, and its clinical manifestations are nonspecific and lack of etiological manifestations. The diagnosis is difficult, which often leads to misdiagnosis. We report a case of endometriosis which…

OBJECTIVE: Recurrent pregnancy loss (RPL) patients have higher absolute numbers of decidual natural killer (dNK) cells with elevated intracellular IFN-γ levels leading to a pro-inflammatory cytokine milieu, which contributes to RPL pathogen…

BACKGROUND: Gynaecologists should be aware of a rare obstructive Mullerian duct abnormality like Robert's uterus and perform further surgery when necessary. CASE SUMMARY: We report a 41-year-old mother of two children with Robert's uterus …

PURPOSE: The window of implantation (WOI) is a brief period during which the endometrium is receptive to embryo implantation. This study investigated the relationship between miR-135a-5p and endometrial receptivity. METHODS: Peripheral blo…

OBJECTIVE: To explore the value of magnetic resonance imaging (MRI) and clinical features in identifying ovarian thecoma-fibroma (OTF) with cystic degeneration and ovary adenofibroma (OAF). METHODS: A total of 40 patients with OTF (OTF gro…

The sex ratio shift was observed in peoples who underwent ART treatment. Moreover, there is limited evidence on differences in sex ratio between single frozen-thawed blastocyst morphology, insemination type and transfer days. So further res…

IMPORTANCE: Adenomyosis is a common chronic gynecological disorder, and its treatment is an unmet need. New therapies need to be developed. Mifepristone is being tested for adenomyosis treatment. OBJECTIVE: To determine whether mifepriston…