Serdar Bulun

Adenomyosis is an important clinical condition with uncertain prevalence, and clinical focus on adenomyosis in patients undergoing assisted reproductive technology (ART) has increased during recent years. Recognizing the limited clinical kn…

BACKGROUND: Aberrant progesterone signaling has been demonstrated in mechanistic studies to be a shared common pathway in fibroids and endometriosis. Progesterone receptor modulation with the selective progesterone receptor modulator (SPRM)…

本研究では, 子宮内膜症および子宮腺筋症の発生・進展における幹細胞の役割を明らかにするために, ヒト内膜細胞を用いた腹膜内膜症モデルマウスの開発を行い, 磁性体により内膜症様病変をマウス壁側腹膜の任意の位置に局在させ得る戦略が可能で有ることを示した。同時に, 新たに幹細胞標識追跡法を開発することで, 組織(病変)再構成過程における幹細胞の振る舞いを検証できるin vivoシステムを構築し得た。さらに, 子宮腺筋症の類縁疾患である子宮平滑筋腫の病因メカニズムに幹細胞とWNT/β…

Endometriosis is a chronic disease that affects millions of reproductive-age women. Despite the destructive and invasive nature of endometrioses, most cases are perpetually benign or eventually regress; however, atypical endometriosis is a …

Endometriosis is one of the most common causes of infertility and chronic pelvic pain and affects 1 in 10 women in the reproductive-age group. Although existence of this disease has been known for over 100 years, our current knowledge of it…

In human endometriotic stromal cells, markedly high levels of aromatase P450 (P450arom) mRNA and promoter II activity are present and can be vigorously stimulated by PGE(2) via a cAMP-dependent pathway to give rise to physiologically signif…