Kadir Buyukcelebi

ORCID: 0009-0009-4653-7931 · 1 paper in corpus

article 2025

Therapeutic targeting of the tryptophan-kynurenine-aryl hydrocarbon receptor pathway with apigenin in MED12-mutant leiomyoma cells

·doi:10.1038/s41417-025-00881-0

Approximately 77.4% of uterine leiomyomas carry MED12 gene mutations (mut-MED12), which are specifically associated with strikingly upregulated expression and activity of the tryptophan 2,3-dioxygenase (TDO2) enzyme, leading to increased co…