Franklin R

ORCID: 0000-0003-2618-0081 · 8 papers in corpus · active 1995-2023

Study types

  • case-report 2
  • article 1

Condition tags

  • endometriosis 3
  • dysmenorrhea 1
  • thoracic_endometriosis 1
2023
Preclinical development of an EP2 antagonist for post-seizure cognitive deficits.
Neuropharmacology ·doi:10.1016/j.neuropharm.2022.109356

Cognitive comorbidities can substantially reduce quality of life in people with epilepsy. Inflammation is a component of all chronic diseases including epilepsy, as well as acute events like status epilepticus (SE). Neuroinflammation is the…

2022
Second-Generation Prostaglandin Receptor EP2 Antagonist, TG8-260, with High Potency, Selectivity, Oral Bioavailability, and Anti-Inflammatory Properties.
ACS pharmacology & translational science ·doi:10.1021/acsptsci.1c00255

EP2, a G-protein-coupled prostaglandin-E2 receptor, has emerged as a seminal biological target for drug discovery. EP2 receptor activation is typically proinflammatory; therefore, the development of EP2 antagonists to mitigate the severity …

2015
Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition.
Lancet (London, England) ·doi:10.1016/s0140-6736(15)61340-x

BackgroundThe Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable compariso…

2012
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.
Lancet (London, England) ·doi:10.1016/s0140-6736(12)61728-0

BackgroundReliable and timely information on the leading causes of death in populations, and how these are changing, is a crucial input into health policy debates. In the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD…

2012
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.
Lancet (London, England) ·doi:10.1016/s0140-6736(12)61729-2

BackgroundNon-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the o…

article 1998
Relation of endometriosis and neuromuscular disease of the gastrointestinal tract: new insights
Fertility and Sterility ·doi:10.1016/s0015-0282(98)00096-x

ObjectiveTo investigate the neuromuscular activity of the gastrointestinal tract by antroduodenal manometry in women with endometriosis documented by laparoscopy, to assess the effects of diet and drug therapy on symptoms, and to assess the…

case-report 1996
Laparoscopic vaporization of diaphragmatic endometriosis in a woman with epigastric pain: a case report
The Journal of reproductive medicine

BACKGROUND: Endometriosis has been observed in 8-15% of reproductive age women and is commonly found in pelvic and nonpelvic organs. Despite its widespread prevalence, the etiology remains obscure. CASE: A 22-year-old woman with intractabl…

case-report 1995
An incidental diagnosis of well-differentiated papillary mesothelioma in a woman operated on for recurrent endometriosis
Fertility and Sterility ·doi:10.1016/s0015-0282(16)57319-1

The case presented involves a report of severe endometriosis with recurrent disabling dysmenorrhea associated with well-differentiated mesothelioma. Although the course of mesotheliomas is predominantly benign, the diversity of lesions, var…