Daniel C Chai

No ORCID on file · 7 papers in corpus · active 2005-2015

Study types

  • article 4
  • other 2
  • review 1

Condition tags

  • endometriosis 7
article 2015
c-Jun NH2-terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.11.022

ObjectiveTo test the hypothesis that the c-Jun NH2-terminal kinase (JNK) inhibitor (JNKI) bentamapimod (AS602801/PGL5001) can reduce induced endometriosis in baboons.DesignProspective randomized placebo-controlled study.SettingNonhuman prim…

other 2010
Peroxisome proliferator-activated receptor-(gamma) receptor ligand partially prevents the development of endometrial explants in baboons: a prospective, randomized, placebo-controlled study
Endocrinology ·doi:10.1210/en.2009-1076

A prospective, randomized, placebo-controlled study was conducted in a baboon model to determine if a thiazolidinedione agonist of peroxisome proliferator-activated receptor-gamma, pioglitazone, can impede the development of endometriosis. …

article 2007
Effects of anti-TNF-mAb treatment on pregnancy in baboons with induced endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.05.062

ObjectiveHormonal suppressive therapy is not effective for endometriosis-associated subfertility and can even prevent conception. Medical inhibition of TNFalpha, which has been shown to improve conception, is effective in the prevention and…

article 2007
Endometriosis in African Women
Women's health (London, England) ·doi:10.2217/17455057.3.5.629

Endometriosis is a gynecological disorder characterized by the growth of endometrial tissue outside the uterine cavity. Although the prevalence of endometriosis is well documented in women living in developed countries, studies on the preva…

other 2007
PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: a prospective, randomized, placebo- and drug-controlled study
Fertility and sterility ·doi:10.1016/j.fertnstert.2006.12.072

OBJECTIVE: To determine the effects of a thiazolidinedione (TZD) agonist of peroxisome proliferator-activated receptor (PPAR)-gamma, rosiglitazone, in a baboon model of established endometriosis. DESIGN: Prospective, randomized, placebo-co…

review 2007
The baboon as a research model for the study of endometrial biology, uterine receptivity and embryo implantation
Gynecologic and obstetric investigation ·doi:10.1159/000101739

The process of embryo implantation includes attachment of the embryo to the endometrium and penetration through the epithelial layer, decidualization of the basement membrane, invasion of the uterine stroma and access to blood supply. This …

article 2005
Recombinant Human TNFRSF1A (r-hTBP1) Inhibits the Development of Endometriosis in Baboons: A Prospective, Randomized, Placebo- and Drug-Controlled Study1
Biology of reproduction ·doi:10.1095/biolreprod.105.043349

Endometriosis is associated with chronic inflammation, including an increased macrophage activity with increased secretion of cytokines, such as tumor necrosis factor (TNF) or TNF superfamily member 2, previously known as TNFalpha. In the p…