Gnutti B

ORCID: 0000-0001-8583-2583 · 1 paper in corpus

2020

Derangements in HUWE1/c-MYC pathway confer sensitivity to the BET bromodomain inhibitor GS-626510 in uterine cervical carcinoma.

Gynecologic Oncology ·doi:10.1016/j.ygyno.2020.06.484

ObjectiveWhole-exome-sequencing (WES) studies reported c-MYC gene-amplification and HUWE1 gene deletion/mutations in a significant number of cervical-cancer-patients (CC) suggesting HUWE1/c-MYC pathway as potential therapeutic target. We in…