Blengini CS

ORCID: 0000-0003-2978-0955 · 2 papers in corpus

review 2022

Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproduction†

Biology of reproduction ·doi:10.1093/biolre/ioab210

The purpose of meiosis is to generate developmentally competent, haploid gametes with the correct number of chromosomes. For reasons not completely understood, female meiosis is more prone to chromosome segregation errors than meiosis in ma…

lab-animal 2021

Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging

Nature communications ·doi:10.1038/s41467-021-25028-1

Embryonic aneuploidy from mis-segregation of chromosomes during meiosis causes pregnancy loss. Proper disjunction of homologous chromosomes requires the mismatch repair (MMR) genes MLH1 and MLH3, essential in mice for fertility. Variants in…