Cheung LWT

ORCID: 0000-0003-1137-3200 · 2 papers in corpus

2023

APOBEC3B stratifies ovarian clear cell carcinoma with distinct immunophenotype and prognosis.

British journal of cancer ·doi:10.1038/s41416-023-02239-5

BackgroundOvarian clear cell carcinoma (OCCC) is a challenging disease due to its intrinsic chemoresistance. Immunotherapy is an emerging treatment option but currently impeded by insufficient understanding of OCCC immunophenotypes and thei…

2014

Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors.

Cancer cell ·doi:10.1016/j.ccell.2014.08.017

PIK3R1 (p85α regulatory subunit of PI3K) is frequently mutated across cancer lineages. Herein, we demonstrate that the most common recurrent PIK3R1 mutation PIK3R1(R348∗) and a nearby mutation PIK3R1(L370fs), in contrast to wild-type and mu…