K H Fritzemeier

No ORCID on file · 2 papers in corpus

lab-animal 2000

Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist

Journal of medicinal chemistry ·doi:10.1021/jm001000c

Herein we describe the chemical synthesis and pharmacological characterization of a novel, highly potent progesterone receptor (PR) antagonist, ZK 230211. The introduction of a 17alpha-pentafluorethyl side chain in the D-ring of the steroid…

lab-animal 1991

Inhibition of the estradiol-mediated endometrial gland formation by the antigestagen onapristone in rabbits: relationship to uterine estrogen receptors

Endocrinology ·doi:10.1210/endo-129-1-312

There is evidence from previous studies that progesterone antagonists (antigestagens) modify estrogen responses at endometrial and myometrial levels without having affinity to the estrogen receptor (ER). The purpose of the present study was…