Fu J

BackgroundEndometrial organoids, with their three-dimensional structure and robust hormonal responsiveness, have emerged as valuable models for investigating uterine physiology and embryo implantation. However, conventional derivation from …

Background: This study aims to investigate the impact of chronic endometritis (CE) diagnosis and treatment on pregnancy outcomes during hysteroscopic fallopian tube catheterization combined with laparoscopy in infertility patients with pelv…

ABSTRACT: The endometrium is the primary site of embryo implantation. Cellular senescence within the endometrium can be broadly categorised into normal cyclical senescence and pathological excessive senescence. Normal cyclical senescence oc…

Oocyte/embryo defects can result in oocyte maturation arrest, fertilization failure, embryonic arrest, and infertility as well as recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. However, the genet…

BACKGROUND: Endometriosis (EMS) is an estrogen-dependent disease that can lead to chronic pain and infertility. Small ubiquitin-related modifier (SUMO)ylation, a key post-translational modification, has been demonstrated to be associated wi…

Qiu Meng,1 Xingrun Xie,2 Haiyan Wang,1 Shouguo Huang,1 Jie Wang,1 Jiantao Fu,1 Jing Zhang11Department of Obstetrics and Gynecology, Haikou People’s Hospital, The First Affiliated Hospital of Hainan University, Haikou, 570208, People’s Repub…

BACKGROUND: Women with advanced maternal age (AMA) face a significant decline in embryo euploidy rates, leading to reduced fertility and increased risks of adverse pregnancy outcomes. While preimplantation genetic testing for aneuploidy (PG…

In clinical drug development, two fundamental questions must be addressed: what is the success rate of drugs in clinical trial; how does such rate change over time. Here, a dynamic strategy for calculating clinical trial success rate (ClinS…

PURPOSE: This study aims to establish a single-time point RNA-sequencing-based endometrial receptivity test (rsERT) to provide hourly precision of endometrial WOI for patients with recurrent implantation failure (RIF). METHODS: A two-phase…

BACKGROUND: Epidermal cysts are benign subcutaneous masses resulting from the implantation of epithelial cells, following trauma or surgery. Giant spontaneous epidermal cysts of the labia minora are rare. To date, only 3 cases of epidermal …

In this single-center, double-blinded, randomized controlled trial, we investigated whether human umbilical cord-derived mesenchymal stromal cells loaded collagen scaffolds (hUC-MSC/CS) could improve the cumulative live-birth rate (cLBR) in…

Adenomyosis (AM) is recognized as a complex gynecological and endocrine disorder that contributes to infertility and elevates the risk of pregnancy complications; however, its underlying genetic basis remains unidentified. This study aimed …

BACKGROUND: Overweight and obesity can induce an inflammatory milieu in the oocyte microenvironment and are closely associated with reduced assisted reproductive outcomes. OBJECTIVE: How are immune cells, cytokines and lipid profiles alter…

PURPOSE: To evaluate whether the inflammatory proteomics of uterine fluid is feasible in defining the endometrial receptivity phase. METHODS: Inflammatory proteomics of uterine fluid was measured using the OLINK Target-96 Inflammation pane…

Adenomyosis (AM) is characterized as a chronic and progressive disorder with limited therapeutic strategies available. Myometrial fibrosis is a prominent pathological feature of AM, yet the underlying molecular mechanisms remain elusive. Th…

BACKGROUND AND OBJECTIVES: Oligomenorrhea and hypomenorrhea were common conditions in outpatient visit which affected child-bearing aged women, and the conventional progesterone treatment has been related to several side effect and contradi…

BACKGROUND: The gut microbiome functions as a metabolic organ, producing numerous enzymes that influence host health; however, their substrates and metabolites remain largely unknown. RESULTS: We present MicrobeRX, an enzyme-based metaboli…

OBJECTIVE: In order to examine the impact of belimumab on recurrent spontaneous abortion (RSA) women exhibiting B lymphocyte dysfunction. METHODS: This study conducted a retrospective case-control analysis of RSA patients with confirmed B …

PURPOSE: To assess the effectiveness of personalized embryo transfer (pET) in enhancing intrauterine pregnancy rates in women with polycystic ovary syndrome (PCOS) without recurrent implantation failure (RIF). METHODS: This single-center, …

BACKGROUND: Some recent studies have shown that female subclinical hypothyroidism (SCH) is associated with diminished ovarian reserve (DOR). In this study, we aimed to investigate whether serum-free thyroxine (fT4) concentrations within the…

BACKGROUND: Robert's uterus combined with transverse uterine septum is a rare uterine malformation. Only one case has been reported to date, and it is challenging to diagnose and treat. CASE PRESENTATION: Here we report the case of a 19-ye…

Previous work indicated that the implantation and pregnancy rates of women with endometriosis are lower than those of healthy women during in-vitro fertilisation and embryonic transfer. And there are numerous microRNAs (miRNAs) in human ute…

Cervical cancer (CC) is the fourth most common cancer among women worldwide. NLR Family CARD Domain Containing 5 (NLRC5) plays an important role in tumorigenesis. However, its effect and mechanism in CC remains unclear. In this study, we ai…

BACKGROUND: Embryo implantation in a receptive endometrium is crucial for successful pregnancy. Endometrial receptivity (ER) prediction tools based on endometrial transcriptome biomarkers by endometrial biopsy have been used to guide succes…