Mia Ståhle

ORCID: 0000-0002-5904-1312 · 3 papers in corpus
article 2014
Intra-Tissue Steroid Profiling Indicates Differential Progesterone and Testosterone Metabolism in the Endometrium and Endometriosis Lesions
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2014-1913

Aberrant sex steroid signaling is suggested to promote endometriosis growth by several mechanisms, and the tissue concentrations of sex steroids are key determinants of the hormone action. However, their concentrations are only superficiall…

article 2012
Endometrial and Endometriotic Concentrations of Estrone and Estradiol Are Determined by Local Metabolism Rather than Circulating Levels
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2012-1154

CONTEXT: Aberrant estrogen synthesis and metabolism have been suggested to increase local estradiol (E2) concentration in endometriosis and thus to promote the growth of the lesions. However, tissue estrogen concentrations within the endome…

review 2011
Estrogen biosynthesis and signaling in endometriosis
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2011.08.022

Endometriosis is an estrogen-dependent gynecological disease where endometrium-like tissue grows outside uterine cavity. Endometriotic cell proliferation is stimulated by estrogens acting predominantly via their nuclear receptors. Estrogen …