Helen L. Del Puerto

• EMT-related markers show marked heterogeneity across endometriotic lesions • Distinct epithelial, mesenchymal-enriched, and mixed phenotypic patterns were identified • E-cadherin, N-cadherin, and vimentin display variable expression at th…

Background: Inhibins and their co-receptor betaglycan are members of the transforming growth factor β superfamily, a group of signaling molecules that control the differentiation of human endometrium in the secretory phase of the menstrual …

Endometriosis is a chronic condition that affects women of reproductive age worldwide. Although the etiology is still uncertain, it has been characterized as endometrial stroma and glands outside the uterus cavity. Evidence suggests that wo…

Objective: Angiotensin-converting-enzyme 2 (ACE2), the cell surface receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is found in a variety of reproductive tissues. The present study evaluated whether uterine fibroi…

Accurate noninvasive diagnostic tests for endometriosis are still missing. This study evaluated the predictive value of the neuropeptide urocortin 1 (Ucn1) to detect pelvic endometriosis in symptomatic women. We enrolled prospectively 97 co…

Background:Nodal is a growth factor of the transforming growth factor b superfamily that is expressed in high turnover tissues, such as the human endometrium, and in several malignancies. The effects of Nodal are modulated by the coreceptor…

Endometriosis is a gynecological disease characterized by endometrial tissue outside the uterine cavity and it is associated with pelvic pain and infertility. Members of the TGF-beta family initiate their actions through activation of type …

Endometriosis is a chronic benign disease characterized by the presence of abnormally located tissue resembling the endometrium with glands and stroma. This disease has a high degree of morbidity due to chronic pelvic pain and infertility. …