Zhang Z

Gynecological cancers present significant therapeutic challenges due to heterogeneity, drug resistance, and the lack of precise diagnostic tools. Selenium (Se), an essential trace element with intrinsic anticancer activity, has emerged as a…

Infected wounds heal considerably slowly among patients with diabetes because of biofilm barriers and immune dysregulation. Therefore, treatment strategies must simultaneously eliminate infection and accelerate healing. In this study, we pr…

BackgroundPolycystic ovary syndrome (PCOS) is associated with an increased risk of type 2 diabetes mellitus (T2DM), and the risk of PCOS increases in patients with T2DM of reproductive age. The bidirectional link between PCOS and T2DM has b…

Age-related decreases in follicle numbers and oocyte quality are major contributors to the decline in female fertility, which is associated with increased infertility rates. Emerging evidence suggests that targeting granulosa cell senescenc…

INTRODUCTION: Ureteral injuries (UIs) remain a major challenge to clinicians in complex gynecological surgery. In this study, we employed three cases to demonstrate the locations of the ureter prone to injury and the process of blunt ureter…

BACKGROUND: The key biomarkers, therapeutic targets, and pathological mechanisms of endometriosis are urgently needed to be elucidated. The role of CTSZ in EM needs to be clarified, and the potential regulatory mechanisms and corresponding …

Follicular development is a complex and dynamic biological process involving coordinated interactions among endocrine regulation, cellular metabolism, redox homeostasis, mitochondrial function, and immune signaling. Increasing evidence indi…

3-Nitropropionic acid (3-NPA) is an irreversible inhibitor of succinate dehydrogenase (SDH; mitochondrial complex II) that is widely used to model mitochondrial metabolic stress. Direct reproductive studies now show that 3-NPA can increase …

Long non-coding RNA Urothelial carcinoma-associated 1 (UCA1) is a pivotal regulator in the progression of endometriosis (EMs), yet its mechanistic role remains elusive. This study identified UCA1 as a factor promoting glycolysis through bio…

Advanced glycation end products (AGEs) are a group of compounds formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs can be generated in the body or introduced through dietary sources a…

BackgroundThe impact of serum vitamin D levels on the success of assisted reproductive technology (ART) among women with polycystic ovary syndrome (PCOS) has not been fully explored.MethodsThis cohort study enrolled 111 patients with PCOS w…

BackgroundBone nonunion is a major complication in fracture treatment. Despite considerable advancements in fracture care, 5-10% of fractures result in nonunion; This demonstrates the requirement for novel molecules to enhance fracture heal…

AbstractIn order to determine the number of eggs to be retrieved to maximize live birth outcomes, this study aimed to develop a clinical prediction model that would identify important predictors of cumulative live birth rate after intracyto…

To analyze and evaluate the correlation between different lipid metabolism levels and endometriosis. The literatures on lipid metabolism and endometriosis published in databases were searched and collected. The search was conducted up to De…

PurposeTo evaluate the relationships between the sperm DNA fragmentation index (DFI) and semen parameters and its application in fresh embryos via in vitro fertilization and transfer.MethodsA retrospective propensity score matching (PSM) st…

Organoids are rapidly self-organizing 3D in vitro cultures derived from pluripotent stem cells (PSCs) or adult stem cells (ASCs) that possess disease-like characteristics with high success rates. Due to their ability to retain tissue struct…

Peptides are fundamental regulators of metabolism, with several already developed as drugs, including glucagon-like peptide-1-based peptide therapeutics for diabetes and obesity. Despite their established importance, our understanding of th…

OBJECTIVE: With the rising frequency and earlier onset of endometrial cancer (EC), improved surgical skills have emerged as a priority. The objective of this study was to determine the effectiveness and safety of transumbilical laparoendosc…

Neuropathic pain causes plasticity in the nervous system, which is often associated with altered protein synthesis. Proteins are the key executors of cellular functions, and their alteration is closely related to the occurrence of neuropath…

Single and multiple endometrial polyps (EP) are common gynecological conditions with differing recurrence rates, influencing clinical treatment decisions. This study aimed to characterize the reproductive tract microbiome in both subtypes t…

Endometriosis, a persistent inflammatory disease, is associated with pelvic or abdominal pain. The immune system and sensory nervous system show a synergistic effect on regulation of pain. In particular, Interleukin-33 (IL-33) is released a…

BackgroundUterine fibroids(UF), while histologically benign, constitute a pervasive yet inequitable epidemiological phenomenon characterized by disproportionately distributed morbidity burdens that correlate asymmetrically with regional dev…

Endometriosis (EMs) is a chronic, estrogen-dependent disease defined by the presence of endometrial-like tissue outside the uterine cavity. Gut microbiota has emerged as potent inducer for chronic inflammatory disease, yet whether its mecha…

BackgroundThe prognosis of patients with gastric cancer with peritoneal metastasis (GCPM) is exceedingly poor. This study evaluated the efficacy and safety of hyperthermic intraperitoneal chemotherapy (HIPEC) with paclitaxel combined with S…

BackgroundOil-based contrast medium in hysterosalpingography has been recommended as an approach to improve fertility in recent years. However, this approach has rarely been applied to patients with unknown recurrent implantation failure (R…