Chen Y

Yao Hu,1,* Yan Chen,1,* Gaolian Li,1 Qingjing Zou,1 Jiawei Zhan,2 Dongmei Li3 1Department of Obstetrics and Gynecology, Jingzhou Central Hospital, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, People’s Republi…

OBJECTIVE: To evaluate the efficacy of intraoperative adhesion barriers in reducing long-term recurrence and alleviating pelvic pain in patients with endometriosis following laparoscopic surgery. METHODS: A retrospective analysis was perfo…

INTRODUCTION: Embryonic stem cells (ESCs), capable of generating all adult cell types, hold transformative potential for agriculture and biomedicine. However, stable sheep ESCs derivation remains challenging, limiting their application in f…

Meihua Li,1 Xiaohua Zhou,2 Yu Chen11Department of Gynecology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), Changde, Hunan, 415000, People’s Republic of China; 2Hunan P…

PURPOSE: To evaluate changes in immunoexpression of proteins involved in epigenetic regulation in the uterus in female ICR mice following neonatal exposure to tamoxifen. METHODS: Thirty-two neonatal mice were randomly assigned to 2 groups:…

Endometriosis (EM) is a condition that impacts roughly 10% of women within the reproductive age demographic on a global scale. Due to the limitations of conventional diagnostic techniques for endometriosis, a concerted effort is necessary t…

OBJECTIVE: To identify the risk factors for severe primary dysmenorrhea in adolescent girls and provide evidence for clinical prevention and intervention. METHODS: This retrospective study enrolled adolescent girls with primary dysmenorrhe…

OBJECTIVE: To estimate the risk of cesarean scar diverticulum associated with the timing of cesarean section. PATIENTS AND METHODS: This was a retrospective cohort study involving three Chinese hospitals. A total of 11,132 women were inclu…

BACKGROUND: Non-neoplastic gynecological diseases substantially impact women of childbearing age (WCBA), contributing to global burden. Despite growing awareness, disparities in healthcare access remain widespread across regions and socioec…

BACKGROUND: Dysmenorrhea impacts 45% to 95% of women of childbearing age globally. Research on the neuro-immune-endocrine regulatory network has grown by 22.3% annually over the past decade, yet the field faces challenges including fragment…

Endometriosis (EM) is an intractable gynecological condition with uncertain etiology. Gut microbiota have been increasingly implicated in EM, yet the underlying mechanisms remain unclear. Here, we identify a gut microbe-metabolite-uterus ax…

The immune system is a pivotal regulator of reproductive physiology, maintaining tissue homeostasis essential for successful pregnancy while contributing to infertility and reproductive disorders when dysregulated. Natural products represen…

BACKGROUND: Endometriosis (EMS) is an oestrogen-dependent chronic inflammatory disease that primarily manifests as chronic pelvic pain and infertility. EMS-associated infertility is closely linked to diminished ovarian function and oocyte q…

OBJECTIVE: To identify factors associated with clinical pregnancy and live birth in frozen embryo transfer (FET) cycles among women with adenomyosis and to develop internally validated prediction models using readily available clinical, lab…

OBJECTIVE: This retrospective cohort study compares perioperative outcomes of reduced Trendelenburg positioning (≤ 20°) versus conventional steep angles (≥ 30°) in gasless vNOTES for benign gynecologic conditions. METHODS: Of 102 enrolled p…

Osteoarthritis (OA) is a widespread degenerative joint disorder manifesting as chronic pain, functional impairment, and progressive disability, imposing a substantial burden on global public health. Despite extensive research, the precise m…

Adenomyosis (ADM) is a benign condition associated with various gynecological disorders. However, effective treatment options are limited, highlighting the urgent need for novel therapeutic targets. This study identified abnormal activation…

BACKGROUND: Intrauterine adhesions (IUA) are fibrotic scars that impair endometrial regeneration, and compromise fertility. Emerging evidence implicates circular RNAs (circRNAs) in fibrotic remodeling, but it remains unclear how the circRNA…

OBJECTIVES: To investigate the knowledge, attitudes and practices (KAP) regarding mammary gland hyperplasia (MGH) in adult women from Shandong province, China. DESIGN: A cross-sectional study. SETTING: This study was conducted in Shandong…

The paradigm shift of lactate from a mere metabolic byproduct to a pleiotropic signaling molecule, coupled with the discovery of lactylation, provides a crucial framework for understanding how metabolic reprogramming drives systemic patholo…

BACKGROUND: Endometriosis is a chronic inflammatory disease characterized by immune microenvironment dysregulation, with the IL-33/ST2L signaling axis playing a crucial role in macrophage polarization and disease progression. Despite growin…

Chronic pain remains a major clinical challenge, creating a need for safe, non-pharmacological interventions. This narrative mini-review examines two light-based approaches that differ in their sites of action and treatment parameters: visu…

Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder with a complex and yet unresolved etiology. Although ovulation induction therapy can improve ovulatory function, the natural pregnancy rate and pregnancy outco…

BACKGROUND: Ovarian cancer is a major female reproductive health issue with heterogeneous biological features on its subtypes, which may require different therapeutic strategies. Glucagon-like peptide-1 receptor (GLP-1R) agonists were repor…