Simon P Langdon

No ORCID on file · 2 papers in corpus

review 2020

Estrogen Signaling and Its Potential as a Target for Therapy in Ovarian Cancer

Cancers ·doi:10.3390/cancers12061647

The estrogen receptor (ER) has functionality in selected ovarian cancer subtypes and represents a potential target for therapy. The majority (>80%) of high grade serous, low grade serous and endometrioid carcinomas and many granulosa cell t…

lab-animal 2008

Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand-induced selective signaling

Molecular Endocrinology ·doi:10.1210/me.2006-0537

GnRH and its receptor are expressed in human reproductive tract cancers, and direct antiproliferative effects of GnRH analogs have been demonstrated in cancer cell lines. The intracellular signaling responsible for this effect differs from …