Shin EM

ORCID: 0000-0003-2147-6772 · 1 paper in corpus

2021

GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.

Science advances ·doi:10.1126/sciadv.abe2470

What covalent modifications control the temporal ubiquitination of ERα and hence the duration of its transcriptional activity remain poorly understood. We show that GREB1, an ERα-inducible enzyme, catalyzes O-GlcNAcylation of ERα at residue…