Vu-Pham D

No ORCID on file · 2 papers in corpus · active 2011-2012
2012
X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11β-substituted steroids.
The Journal of biological chemistry ·doi:10.1074/jbc.m111.308403

We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed profile PR modulators whose functional activity results from two differing molecular mechanisms. The structure of Asoprisnil bound to the agoni…

2011
Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.
The Journal of biological chemistry ·doi:10.1074/jbc.m111.273029

The progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. We describe here t…