Catriona L. K. Barnes

ORCID: 0000-0002-3526-8002 · 1 paper in corpus · active 2023

Study types

  • rct 1

Condition tags

  • endometriosis 1
rct 2023
Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis
Drugs in R&D ·doi:10.1007/s40268-023-00427-5

INTRODUCTION: BAY1128688 is a selective inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), an enzyme implicated in the pathology of endometriosis and other disorders. In vivo animal studies suggested a potential therapeutic appli…