Hiroshi Ogawa

ORCID: 0000-0003-0236-6535 · 3 papers in corpus
article 2017
Cancer-Associated Mutations in Endometriosis without Cancer
New England Journal of Medicine ·doi:10.1056/nejmoa1614814

BACKGROUND: Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benig…

other 2017
CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc ·doi:10.1038/modpathol.2016.160

Ovarian clear cell carcinoma is a unique type of ovarian cancer, often derived from endometriosis, and advanced-stage disease has a dismal prognosis primarily due to the resistance to conventional chemotherapy. Previous studies have shown f…

article 2012
Loss of ARID1A Expression Is an Early Molecular Event in Tumor Progression From Ovarian Endometriotic Cyst to Clear Cell and Endometrioid Carcinoma
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society ·doi:10.1097/igc.0b013e31826b5dcc

ObjectivesARID1A is a recently identified tumor suppressor participating in chromatin remodeling. Somatic inactivating mutations of ARID1A and loss of its expression occur frequently in ovarian clear cell and endometrioid carcinomas and in …