Zhengchao Wang

ORCID: 0000-0001-7439-9630 · 3 papers in corpus
2026
The Succinate-HIF-1α-NLRP3 Axis in 3-Nitropropionic Acid-Induced Ovarian Dysfunction: A Testable Metabolic-Inflammatory Framework.
Biology ·doi:10.3390/biology15171557

3-Nitropropionic acid (3-NPA) is an irreversible inhibitor of succinate dehydrogenase (SDH; mitochondrial complex II) that is widely used to model mitochondrial metabolic stress. Direct reproductive studies now show that 3-NPA can increase …

2022
P38α MAPK is a gatekeeper of uterine progesterone responsiveness at peri-implantation via Ube3c-mediated PGR degradation.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2206000119

Estrogen and progesterone specify the establishment of uterine receptivity mainly through their respective nuclear receptors, ER and PR. PR is transcriptionally induced by estrogen-ER signaling in the endometrium, but how the protein homeos…

article 2007
ROLE OF PHOSPHODIESTERASE IN CYCLIC NUCLEOTIDE SIGNALING DURING OVARIAN FOLLICULAR DEVELOPMENT IN THE RAT
·doi:10.1093/biolreprod/77.s1.183

Cyclic nucleotides, cyclic AMP (cAMP) and cyclic GMP (cGMP), as second messages play potential roles in the mammalian ovarian functions. The cellular level of cyclic nucleotide (cAMP/cGMP) is largely dependent on the activity of phosphodies…