Martin Empting

No ORCID on file · 2 papers in corpus · active 2014-2015

Study types

  • other 2

Condition tags

  • endometriosis 2
other 2015
Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme
European journal of medicinal chemistry ·doi:10.1016/j.ejmech.2015.08.030

17β-Estradiol (E2), the most potent human estrogen, is known to be involved in the etiology of estrogen-dependent diseases (EDD) like breast cancer and endometriosis. 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyses the last ste…

other 2014
Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker
European journal of medicinal chemistry ·doi:10.1016/j.ejmech.2014.05.074

Estradiol is the most potent estrogen in humans. It is known to be involved in the development and proliferation of estrogen dependent diseases such as breast cancer and endometriosis. The last step of its biosynthesis is catalyzed by 17β-h…