Sakthivignesh Ponandai‐Srinivasan

article 2023

P-346 Migration-associated microRNAs are dysregulated in endometriosis: potential diagnostic biomarkers

·doi:10.1093/humrep/dead093.704

Abstract Study question What is the role of dysregulated endometrial microRNAs (miRNAs) in the development of endometriosis? Summary answer Dysregulated miRNAs in the endometrium of women with endometriosis can also be found in endometrioma…

article 2020

Syndecan-1 modulates the invasive potential of endometrioma via TGF-β signalling in a subgroup of women with endometriosis

Human Reproduction ·doi:10.1093/humrep/deaa164

STUDY QUESTION: What is the physiological role of transforming growth factor-beta (TGF-β1) and syndecans (SDC1, SDC4) in endometriotic cells in women with endometriosis? SUMMARY ANSWER: We observed an abnormal, pro-invasive phenotype in a s…

article 2019

58 SYNDECAN-1 Inhibition reverses the pre-malignant phenotype of endometrioma through TGF-BETA signalling: potential implications in endometriosis associated ovarian cancer

·doi:10.1136/ijgc-2019-igcs.58

other 2018

Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis

Human Reproduction ·doi:10.1093/humrep/dey241

STUDY QUESTION: Is there molecular evidence for a link between endometriosis and endometriosis-associated ovarian cancers (EAOC)? STUDY ANSWER: We identified aberrant gene expression signatures associated with malignant transformation in a…

review 2018

DNA methylation alterations—potential cause of endometriosis pathogenesis or a reflection of tissue heterogeneity?†

Biology of reproduction ·doi:10.1093/biolre/ioy067

Alterations in the DNA methylation pattern of endometriotic lesions and endometrium of endometriosis patients have been proposed as one potential factor accompanying the endometriosis development. Although many differentially methylated gen…