Brown P

ORCID: 0000-0002-7341-2503 · 7 papers in corpus · active 2007-2023
2023
iScience ·doi:10.1016/j.isci.2023.107616

WNK1 is an important regulator in many physiological functions, yet its role in male reproduction is unexplored. In the male germline, WNK1 is upregulated in preleptotene spermatocytes indicating possible function(s) in spermatogenic meiosi…

2017
PloS one ·doi:10.1371/journal.pone.0183013

BackgroundAbdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposit…

2011
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2010-2971

ContextThe human endometrium has an exceptional capacity for repeated repair after menses, but its regulation remains undefined. Premenstrually, progesterone levels fall and prostaglandin (PG) F₂α synthesis increases, causing spiral arterio…

2009
Journal of clinical oncology : official journal of the American Society of Clinical Oncology ·doi:10.1200/jco.2008.20.5179

PURPOSE To update the 2002 American Society of Clinical Oncology guideline on pharmacologic interventions for breast cancer (BC) risk reduction. METHODS A literature search identified relevant randomized trials published since 2002. Primary…

2009
BMC cancer ·doi:10.1186/1471-2407-9-330

BackgroundEndometrial cancer is the most common gynaecological malignancy; risk factors include exposure to oestrogens and high body mass index. Expression of enzymes involved in biosynthesis of oestrogens and prostaglandins (PG) is often h…

2009
Biochimica et biophysica acta ·doi:10.1016/j.bbamcr.2009.09.018

Pro-inflammatory mediators, like prostaglandin (PG) and chemokines, promote tumourigenesis by enhancing cell proliferation, migration of immune cells and recruitment of blood vessels. Recently we showed elevated expression of the chemokine …

2007
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2006-0253

The asynchronous secretion of gonadotrope LH and FSH under the control of GnRH is crucial for ovarian cyclicity but the underlying mechanism is not fully resolved. Because prostaglandins (PG) are autocrine regulators in many tissues, we det…