Jérémy Wrobel

ORCID: 0000-0001-5165-2138 · 2 papers in corpus · active 2021-2025

Study types

  • article 2
article 2025
Efficacy and Safety of Danazol in Pulmonary Fibrosis Associated With Short Telomeres: A Phase 2 Randomized Clinical Trial
·doi:10.1164/ajrccm.2025.211.abstracts.a1010

Abstract RATIONALE: Telomere attrition is identified in a significant number of patients with pulmonary fibrosis (PF) and is predictive of worse survival. Danazol, a synthetic sex hormone, has shown promise in telomere biology disorders but…

article 2021
TELO-SCOPE study: a randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis
·doi:10.1136/bmjresp-2021-001127

INTRODUCTION: Recent discoveries have identified shortened telomeres and related mutations in people with pulmonary fibrosis (PF). There is evidence to suggest that androgens, including danazol, may be effective in lengthening telomeres in …