Goddard ME

ORCID: 0000-0001-9917-7946 · 4 papers in corpus
2014
Statistical power to detect genetic (co)variance of complex traits using SNP data in unrelated samples.
PLoS genetics ·doi:10.1371/journal.pgen.1004269

We have recently developed analysis methods (GREML) to estimate the genetic variance of a complex trait/disease and the genetic correlation between two complex traits/diseases using genome-wide single nucleotide polymorphism (SNP) data in u…

other 2013
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis
Human molecular genetics ·doi:10.1093/hmg/dds491

Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide association studies (GWASs) for these diseases ha…

2013
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Nature genetics ·doi:10.1038/ng.2711

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype da…

article 2012
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis

Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide association studies (GWASs) for these diseases ha…