Titus L

No ORCID on file · 10 papers in corpus · active 2013-2025

Study types

  • rct 1

Condition tags

  • endometriosis 1
2025
The American journal of clinical nutrition ·doi:10.1016/j.ajcnut.2025.02.004

BackgroundPrognosis after a diagnosis of invasive epithelial ovarian cancer is poor. Some studies have suggested modifiable behaviors, like diet, are associated with survival but the evidence is inconsistent.ObjectivesThis study aims to poo…

2024
American journal of human genetics ·doi:10.1016/j.ajhg.2024.04.011

To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases an…

2024
American Journal of Epidemiology ·doi:10.1093/aje/kwae076

Limited estimates exist on risk factors for epithelial ovarian cancer (EOC) in Asian, Hispanic, and Native Hawaiian/Pacific Islander women. Participants in this study included 1734 Asian (n = 785 case and 949 control participants), 266 Nati…

2023
Journal of the National Cancer Institute ·doi:10.1093/jnci/djad011

BackgroundThe role of ovulation in epithelial ovarian cancer (EOC) is supported by the consistent protective effects of parity and oral contraceptive use. Whether these factors protect through anovulation alone remains unclear. We explored …

2022
Journal of the National Cancer Institute ·doi:10.1093/jnci/djac160

BackgroundKnown risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort.MethodsSingl…

2022
European journal of human genetics : EJHG ·doi:10.1038/s41431-021-00987-7

Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard…

2021
Journal of the National Cancer Institute ·doi:10.1093/jnci/djaa099

BackgroundParity is associated with decreased risk of invasive ovarian cancer; however, the relationship between incomplete pregnancies and invasive ovarian cancer risk is unclear. This relationship was examined using 15 case-control studie…

2019
Reproductive toxicology (Elmsford, N.Y.) ·doi:10.1016/j.reprotox.2018.12.008

BackgroundAnimal studies suggest that prenatal exposure to diethylstilbestrol (DES) causes epigenetic alterations in primordial germ cells that affect the next generation, but human studies are sparse.MethodsWe assessed hormonally mediated …

rct 2018
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology ·doi:10.1158/1055-9965.EPI-18-0203

BACKGROUND: Randomized trials using the biomarker cancer antigen (CA) 125, with or without pelvic ultrasound, have failed to show a clear benefit of general population screening for ovarian cancer. In part, this may be due to a lack of info…

2013
Cancer causes & control : CCC ·doi:10.1007/s10552-013-0266-1

PurposeTest the hypothesis that puerperal mastitis may alter immunity related to the mucin (MUC) family of glycoproteins and lower risk of ovarian cancer.MethodsIn two case-control studies conducted in New England between 1998 and 2008, we …